|
Neoplasm Metastasis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The following clusters were found in the dendrogram: Nrf2 and p21 with ATP5B and GADPH in all the tissues and with NRF1 in all except the tumor tissues with metastasis; Bach1 with ATP5B and GAPDH in the tumor tissues; Keap1 with p62 in all the tissues, with LC3 in the tumor tissues and with NRF1 and HO1 in the tumor tissues with metastasis.
|
31796664 |
2020 |
|
Idiopathic Pulmonary Fibrosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Mitochondria in AMs from IPF patients had prominent morphological defects and impaired transcription paralleled to a significant reduction of mitochondria homeostasis regulators PINK1, PARK2 and NRF1. mtROS, was significantly higher in IPF and associated with reduced expression of mitochondria-encoded oxidative phosphorylation (OXPHOS) genes.
|
31775876 |
2019 |
|
Encephalomyelitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Together, these findings suggest that a combination of subunit displacement and reduced Nrf1 expression may be responsible for c-20S impairment in EAE.
|
31709534 |
2020 |
|
Diabetes Mellitus
|
0.020 |
Biomarker
|
group |
BEFREE |
According to the results, ASIV can regulate energy metabolism by regulating the release of PGC‑1α and NRF1 to rescue the abnormal energy metabolism caused by diabetes mellitus, thus decreasing the myocardial damage caused by diabetic cardiomyopathy.
|
31702040 |
2019 |
|
Malignant Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
The prognostic significance of the major redox regulator nuclear factor erythroid-2-related factor (NRF2) is recognized in many cancers, but the role of NRF1 is not generally well understood in cancer.
|
31687076 |
2019 |
|
Primary malignant neoplasm
|
0.050 |
Biomarker
|
group |
BEFREE |
The prognostic significance of the major redox regulator nuclear factor erythroid-2-related factor (NRF2) is recognized in many cancers, but the role of NRF1 is not generally well understood in cancer.
|
31687076 |
2019 |
|
melanoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The immunohistochemical expression of nuclear NRF1 decreased from benign to dysplastic naevi (<i>p</i> < 0.001) and to primary melanoma (<i>p</i> < 0.001) and from primary melanoma to metastatic lesions (<i>p</i> = 0.012).
|
31687076 |
2019 |
|
Melanocytic nevus
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Also, NRF1 mRNA levels decreased from benign naevi to dysplastic naevi (<i>p</i> = 0.034).
|
31687076 |
2019 |
|
Optic Atrophy 1
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Additionally, the hormone induced the expression of the nuclear respiratory factors 1 and 2 (Nrf-1 and Nrf-2), the mitochondrial transcription factors A (Tfam) and B2 (TFB2M), and the optic atrophy 1 (OPA1).
|
31676390 |
2020 |
|
Nicotinamide adenine dinucleotide coenzyme Q reductase deficiency
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We show that complex I deficiency leads to a redox potential alteration and a significant reduction of sirtuin 1 (SIRT1) expression, a major deacetylase sensitive to the cellular redox state, and NRF1 the downstream target of SIRT1.
|
31655048 |
2020 |
|
Retinoblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, the results of the present study have uncovered a novel mechanism in which CXCR4 expression is regulated by Nrf‑1 in WERI‑Rb1 cells, thereby identifying novel potential targets for the treatment of RB, and providing evidence for the clinical application of TMP in adjuvant retinoblastoma therapy.
|
31322174 |
2019 |
|
Pelvic Organ Prolapse
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
There was no significant difference in the TFAM(p = 0.377), NRF-1 and NRF-2 expression between the POP and non-POP groups (p = 0.647; p = 0.682).
|
31307745 |
2019 |
|
Virus Diseases
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Interestingly, the virus infection at the late stage (at 16 h after infection) stimulated TFAM expression but decreased the levels of both NRF1 and NRF2, indicating that virus infection activated TFAM signaling independent of either NRF1 or NRF2.
|
31011285 |
2019 |
|
Malignant Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
These data represent that inhibition of NRF1 degradation is a potential therapeutic strategy against cancer.
|
30833558 |
2019 |
|
Primary malignant neoplasm
|
0.050 |
Biomarker
|
group |
BEFREE |
These data represent that inhibition of NRF1 degradation is a potential therapeutic strategy against cancer.
|
30833558 |
2019 |
|
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Here, we show that SIAH2-NRF1 axis remodels tumor microenvironment through regulating tumor mitochondrial function, tumor-associated macrophages (TAMs) polarization and cell death for tumor maintenance and progression.
|
30833558 |
2019 |
|
Tumor Progression
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The SIAH2-NRF1 axis spatially regulates tumor microenvironment remodeling for tumor progression.
|
30833558 |
2019 |
|
Diffuse Large B-Cell Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Nrf1 and Nrf2 are relevant in disease presentation and overall survival in high-risk DLBCL.
|
30755497 |
2019 |
|
B-Cell Lymphomas
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Furthermore, overexpression of NRF‑1 increased the expression of B‑cell lymphoma‑2, hypoxia inducible factor‑1α and NRF‑2.
|
30628711 |
2019 |
|
Liver neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Liver-specific knockout of Nrf1 in the mouse leads to spontaneous development of non- alcoholic steatohepatitis with dyslipidemia, and then its deterioration results in hepatoma, but the underlying mechanism remains elusive to date.
|
30562963 |
2018 |
|
Dyslipidemias
|
0.010 |
Biomarker
|
group |
BEFREE |
Liver-specific knockout of Nrf1 in the mouse leads to spontaneous development of non- alcoholic steatohepatitis with dyslipidemia, and then its deterioration results in hepatoma, but the underlying mechanism remains elusive to date.
|
30562963 |
2018 |
|
Liver carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Liver-specific knockout of Nrf1 in the mouse leads to spontaneous development of non- alcoholic steatohepatitis with dyslipidemia, and then its deterioration results in hepatoma, but the underlying mechanism remains elusive to date.
|
30562963 |
2018 |
|
Nonalcoholic Steatohepatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Liver-specific knockout of Nrf1 in the mouse leads to spontaneous development of non- alcoholic steatohepatitis with dyslipidemia, and then its deterioration results in hepatoma, but the underlying mechanism remains elusive to date.
|
30562963 |
2018 |
|
Malignant Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
Overall, our study provides a framework for manipulating the TIP60-Nrf1 axis to alter proteasome function in various human diseases, including cancer.
|
30559296 |
2019 |
|
Primary malignant neoplasm
|
0.050 |
Biomarker
|
group |
BEFREE |
Overall, our study provides a framework for manipulating the TIP60-Nrf1 axis to alter proteasome function in various human diseases, including cancer.
|
30559296 |
2019 |